★ Deaconess Guesthouse · Iconic Luxury on the Ohio River · Walk to Downtown Jeffersonville & Louisville ★
★ A Historic Riverfront Estate Reimagined for Modern Luxury
Experience Deaconess Guesthouse—an extraordinary 1800s landmark transformed into a boutique-style luxury retreat. Once Jeffersonville’s first public hospital, this architecturally rich estate has been fully restored and thoughtfully designed by Charming Vacation Homes to offer an upscale, one-of-a-kind stay along the Ohio River.
This rare riverfront setting provides peaceful, panoramic water views while placing you just steps from downtown Jeffersonville and a short stroll across the Big Four Bridge into downtown Louisville’s museums, bourbon distilleries, entertainment and top attractions. Few homes in the region offer this level of convenience paired with true riverfront tranquility.
★ Luxury Accommodations Tailored for Exceptional Group Stays
Perfect for business retreats, milestone celebrations, wedding groups, and multi-family getaways, the home features:
- 8 beautifully appointed bedrooms
- 6 spa-inspired bathrooms
- Space for up to 24 guests across four private suites
Every room blends timeless character with modern comfort—custom furnishings, warm textures, elegant details and inviting spaces that elevate your stay.
Exclusive Amenities & Signature Spaces
★ Private Hot Tub & Fire Pit — Relax riverside after exploring the city
★ Wraparound Porches & Balconies — Perfect for morning coffee or sunset cocktails
★ Stargazing Dome — A whimsical hideaway loved by kids and adults alike
★ Ample On-Site Parking — A rare convenience for large groups and events
★ Unmatched Walkable Location
Step outside and enjoy the best of both cities:
- Walk to Downtown Jeffersonville
- Restaurants, cafés, boutique shops, festivals, riverfront parks
- Walk or drive minutes to Downtown Louisville
- Distilleries, Museum Row, KFC Yum! Center, Fourth Street Live!, Waterfront Park, performing arts venues
★ Nearby Attractions:
1. The Kentucky Bourbon Trail
2. Churchill Downs
3. Big Four Walking Bridge
4. Scenic biking paths and riverfront trails
Whether you’re exploring local flavors or enjoying outdoor recreation, everything is easily within reach.
★ Where Luxury Meets Lasting Memories
From starlit evenings in the hot tub to quiet moments on the porch watching riverboats drift by, Deaconess Guesthouse creates an atmosphere made for connection and celebration. It’s more than a place to stay—it’s a venue for unforgettable experiences.
★ Now Booking Luxury Stays & Private Events
Ideal for:
1. Corporate retreats & leadership offsites
2. Family reunions & friend gatherings
3. Wedding stays & special milestones
4. Weekend getaways & holiday celebrations
Reserve your stay at one of the region’s most distinctive riverfront estates—where history, luxury and exceptional hospitality come together.
** Please note: A strict cancellation policy applies for Derby and Bourbon & Beyond dates. **
★ CONVENIENT LOCATION
The house is centrally located and is within a 10-15 minute Uber/Lyft drive to most locations:
- Churchill Downs (DERBY) - 7.7 miles (15 mins)
- Big Four Walking Bridge (Connecting KY and IN) - 0.4 miles (2 mins)
- Downtown Louisville/ 4th Street Live - 2.4 miles (6 mins)
- Waterfront Park - 3.4 miles (9 mins)
- KFC Yum Center - 2.3 miles (7 mins)
- Papa Johns Stadium (Cardinal Stadium) - 6.4 miles (11 mins)
- University of Louisville - 6.5 miles (12 mins)
- Kentucky Fairgrounds - 6.5 miles (10 min)
- Kentucky Exposition Center - 6.7 miles (11 mins)
- Kentucky Kingdom - 7.4 miles (13 mins)
- Highland Festival Grounds - 8.5 miles (12 mins)
- Louisville Airport - 8.6 miles (10 mins)
- Louisville Mega Cavern - 10.2 miles (19 mins)
- Ford LAP Plant - 10.9 miles (16 mins)
- UPS Worldport - 11.2 miles (20 mins)
- Waverly Hills Sanatorium - 17 miles (30 mins)
- Valhalla Golf Club - 19 miles (27 mins)
PROPERTY HIGHLIGHTS
★ Riverfront Luxury Retreat – Experience unforgettable Ohio River sunrises with downtown Jeffersonville at your doorstep and Louisville just a short stroll across the Big Four Bridge.
★ Timeless Historic Elegance – A masterfully restored landmark blending classic architecture with modern luxury and beautifully curated interiors.
★ Unbeatable Walkable Location – Steps to cafés, boutiques, riverfront parks, restaurants, and Louisville’s top attractions—where peaceful waterfront living meets vibrant city energy.
★ Designed for Groups – Eight stylish bedrooms, six spa-inspired bathrooms and bright gathering spaces offer the perfect balance of togetherness and privacy.
★ Culinary Convenience – Four fully equipped kitchens with premium appliances make hosting, cooking, and multi-family stays effortless.
★ Inviting Outdoor Spaces – Enjoy morning coffee on covered porches, unwind on private balconies, and savor the calm of the river all day long.
★ Private Backyard Oasis – Relax in the hot tub, gather around the riverfront fire pit, dine in the gazebo/Hyperdome and enjoy lawn games with family and friends.
★ Entertainment for All – Multiple lounges, Smart TVs, and indoor/outdoor games ensure everyone has something to enjoy.
★ Kid & Pet Friendly – Thoughtful amenities welcome every member of your group, including little ones and furry companions.
★ Your Premier Riverfront Escape – Where historic charm meets elevated comfort and a location that’s second to none—crafted for an exceptional stay you’ll always remember.
★ 2026 TOP EVENTS
- CROSS 2026 – Jan 1, 2026
- A Salute to the Rat Pack – Jan 2–3, 2026
- Trevor Wallace – Jan 9, 2026
- Harlem Globetrotters – Jan 16, 2026
- Neko Case – Jan 20, 2026
- Dinosaur World Live – Jan 23, 2026
- Candlelight: Coldplay & Imagine Dragons – Jan 23, 2026
- The Millennium Tour – Jan 23, 2026
- Bluegrass World of Wheels – Jan 24–25, 2026
- NouLou Chamber Players – Feb 2, 2026
- Black Violin – Feb 5, 2026
- The Great Gatsby – Feb 10–15, 2026
- Gary Owen – Feb 13, 2026
- Kinetic Light – Feb 14, 2026
- Cody Johnson – Feb 14, 2026
- Kindle the Flame – Feb 14, 2026
- NEEDTOBREATHE (Acoustic) – Feb 17, 2026
- Saxsquatch – Feb 20, 2026
- Growers Not Showers Party – Feb 21, 2026
- USA Gymnastics Winter Cup – Feb 20–22, 2026
- John Crist – Feb 22, 2026
- moe. – Feb 22, 2026
- Bourbon Classic – Feb 25–28, 2026
- The Lone Bellow – Feb 25, 2026
- LDB Fest – Feb 27–28, 2026
- Josiah Queen – Mar 7, 2026
- NouLou Chamber Players (Schubertiade) – Mar 9, 2026
- Sweet Honey in the Rock – Mar 29, 2026
- America: Happy Trails Tour – Apr 2, 2026
- Chelsea Handler – Apr 12, 2026
- Thunder Over Louisville – Apr 18, 2026
- Brandon Lake – Apr 24, 2026
- Great Steamboat Race – Apr 29, 2026
- Kentucky Oaks – May 1, 2026
- Kentucky Derby – May 2, 2026
- The Invaders – May 11, 2026
- World Oddities Expo – Jun 13–14, 2026
- Forrest Frank – Jul 28, 2026
- Kentucky State Fair – Aug 20–30, 2026
- Ray LaMontagne – Sep 6, 2026
- Big Four Art Festival – Sep 12–13, 2026
- Louder Than Life – Sep 17–20, 2026
- Bourbon & Beyond – Sep 24–27, 2026
- St. James Court Art Show – Oct 3–4, 2026
- NuLu Fest – Oct 9–11, 2026
- Halloween & Haunted Attractions – Oct 24–31, 2026
- Thanksgiving Week Travel – Nov 25–29, 2026
- Light Up Louisville – Nov 27, 2026
- Christmas at Frazier Museum – Dec 5–20, 2026
- Louisville Ballet: The Nutcracker – Dec 2026
- New Year’s Eve at Fourth Street Live! – Dec 31, 2026
★ 2026 TRADE SHOWS & EXPOS
- North American Honey Bee Expo — Jan 8–10, 2026
- Louisville Home + Garden Show — Jan 9–11, 2026
- Louisville Manufactured Housing Show — Jan 14–16, 2026
- NVP Product Expo — Jan 22–25, 2026
- Louisville Boat, RV & Sportshow — Jan 28–Feb 1, 2026
- Show of Shows (Military Antiques) — Jan 29–Feb 1, 2026
- National Farm Machinery Show — Feb 11–14, 2026
- Ace Hardware Spring Convention — Feb 24–26, 2026
- GAMA Expo — Mar 1–5, 2026
- Mid-America Trucking Show (MATS) — Mar 26–28, 2026
- Connect Spring Marketplace — Apr 14–16, 2026
- World Oddities Expo — Jun 13–14, 2026
- Equip Expo — Oct 20–23, 2026
★ OPTIONAL CONCIERGE ENHANCEMENTS
Make your stay even more effortless:
✔ Grocery Pre-Stocking – Walk into a fully prepared kitchen.
✔ Private Chef Experience – Perfect for celebrations or elevated evenings in.
✔ Custom Bourbon Tours & Chauffeur Services – Personalized for your group.
★ PEACE OF MIND AND EXCEPTIONAL GUEST COMFORT
✔ Professionally cleaned and sanitized
✔ Contactless self check-in for your convenience
✔ 24/7 guest support throughout your stay
✔ Exterior-only security cameras at the front of the home for guest safety and property protection
NOTE:
1. 25+ to book.
2. House Rules Required: E-sign rental agreement and submit a $500 security hold via secure OwnerRez (placed 2 days before arrival, released 7 days after departure if no damage).
3. Strict cancellation for Derby & Bourbon & Beyond dates.
4. No visitors unless pre-approved by the host.
5. Exterior cameras only (parking area & front door). No interior or backyard cameras.
6. Dome use: Not recommended during hot summer months.
7. No early check-in / late check-out on same-day turnovers.
8. When available: $100 (≤2 hrs), $250 (2–4 hrs), full night rate (>4 hrs).
9. Non-Airbnb refunds incur a 3% Stripe processing fee.
PLEASE REVIEW THE HOUSE RULES BEFORE BOOKING. THANKS!