Well, this is a bit of a curiosity!
Sistina Vatican Rooms must, a one time, have been an ordinary apartment in an ordinary apartment building, which just happens to be very close to the Vatican. In fact, when you reach the address, that is what you see; an unremarkable apartment building, a front door, like so many other apartment building front doors... It's just that, among the buzzers, one bears the name Sistina Vatican Rooms instead of that of a family. For these two travellers, already jostled by the tourist hoards on the way from the station, the prospect of an escape into a world inhabited by ordinary Romans came as a relief.
The experience didn't disappoint. Stepping out of the lift, we were greeted by Ambra who was as welcoming and helpful in person as she had been by e-mail and WhatsApp.
No-one else was 'at home', so we were given a quick tour. There are two 'rooms' available here. The first one, the main part of the old apartment, is very spacious and would be suitable for a family. It faces the main street, so there's a little bit of street noise, but it looks lovely. The second one is quite small in comparison, a double room with en suite bathroom, fridge, wardrobe and breakfast table next to a window overlooking the inner courtyard. It's clean, sunny and beautifully calm; you'd hardly know you're in Rome. Simple breakfast, coffee & WiFi included.
Don't be put off by the modest size; you're not going to spend time here, other than to recover from sightseeing!